One strength per vialEvery Zepbound vial holds one strength. A 5 mg single-dose vial is one 5 mg dose; a 5 mg multi-dose vial is four 5 mg doses. Neither is meant for measuring a different dose out of it.[1]
Zepbound vial strengths: single-dose vials
Each single-dose vial contains 0.5 mL of solution with no preservative. The strength on the vial is the dose in that 0.5 mL.[1]
| Strength | Volume | Concentration | Full vial (U-100 scale) | Vial first offered |
|---|---|---|---|---|
| 2.5 mg | 0.5 mL | 5 mg/mL | 50 units | August 27, 2024[3] |
| 5 mg | 0.5 mL | 10 mg/mL | 50 units | August 27, 2024[3] |
| 7.5 mg | 0.5 mL | 15 mg/mL | 50 units | February 25, 2025[4] |
| 10 mg | 0.5 mL | 20 mg/mL | 50 units | February 25, 2025[4] |
| 12.5 mg | 0.5 mL | 25 mg/mL | 50 units | August 2025[5] |
| 15 mg | 0.5 mL | 30 mg/mL | 50 units | August 2025[5] |
Single-dose vials come in cartons of 1 or 4.[1] The label says: “Throw away all opened vials after use, even if there is medicine left in the vial.”[1]
Multi-dose vials (approved January 2026)
On January 7, 2026 the FDA approved a multi-dose Zepbound vial.[6] It holds 2.4 mL: four weekly doses of 0.6 mL each, with benzyl alcohol and phenol as preservatives.[1]
| Dose per injection | Total in vial | Concentration | One dose (U-100 scale) |
|---|---|---|---|
| 2.5 mg / 0.6 mL | 10 mg / 2.4 mL | 4.17 mg/mL | 60 units |
| 5 mg / 0.6 mL | 20 mg / 2.4 mL | 8.33 mg/mL | 60 units |
| 7.5 mg / 0.6 mL | 30 mg / 2.4 mL | 12.5 mg/mL | 60 units |
| 10 mg / 0.6 mL | 40 mg / 2.4 mL | 16.67 mg/mL | 60 units |
| 12.5 mg / 0.6 mL | 50 mg / 2.4 mL | 20.83 mg/mL | 60 units |
| 15 mg / 0.6 mL | 60 mg / 2.4 mL | 25 mg/mL | 60 units |
As of November 13, 2026, LillyDirect lists three Zepbound formats (KwikPen, single-dose vial and single-dose pen) and does not list the multi-dose vial.[7]
How to inject a Zepbound vial: the label instructions
The prescribing information says to use “a 1 mL syringe capable of measuring a 0.5 mL or 0.6 mL dose” and to “always use a new syringe and needle for each injection.” The syringe and needle are not included.[1] The Instructions for Use measure by the millilitre lines on the syringe, not by units:[1]
- Draw air into the syringe to the 0.5 mL line (0.6 mL for a multi-dose vial) and push it into the vial.
- Turn the vial upside down and pull the plunger past the line.
- Slowly push the plunger back up until its tip reaches the 0.5 mL line (0.6 mL for a multi-dose vial).
- Inject under the skin of the abdomen or thigh, or the back of the upper arm if someone else gives it, and hold the needle in for at least 5 seconds.
This is a summary. The Instructions for Use that come with the vials have drawings of each step and are the version to follow.[1] Other label points: “Do not mix ZEPBOUND with any other medicine,” rotate injection sites, and do not use the solution if it is cloudy, discolored or has particles in it.[1]
Storage
Zepbound vials are kept in the fridge; a single-dose vial may spend up to 21 days at room temperature and an unopened multi-dose vial up to 30.[1]
| Situation | Single-dose vial | Multi-dose vial |
|---|---|---|
| Normal storage | Refrigerate at 2–8 °C (36–46 °F) | Refrigerate at 2–8 °C (36–46 °F) |
| Without refrigeration | Up to 30 °C (86 °F) for a total of 21 days | Unopened: up to 30 °C, throw away after 30 days |
| After first use | Single use: discard the vial | Fridge or up to 30 °C; discard after 30 days at room temperature, 30 days after first use, or 4 doses, whichever comes first |
| Always | Do not freeze; keep in the carton to protect from light | Do not freeze; keep in the carton to protect from light |
An April 2026 label update supports moving single-dose vials and pens between the fridge and room temperature within the 21-day limit.[2]
Zepbound vial price
Single-dose vials are sold only through Lilly's self-pay pharmacy, LillyDirect; insurance is not used for them.[7] Prices for a 4-vial fill, checked November 13, 2026:[7]
| Strength | Price | Regular price* | Per weekly dose |
|---|---|---|---|
| 2.5 mg | $299 | $299 | $74.75 |
| 5 mg | $399 | $399 | $99.75 |
| 7.5 mg | $449 | $499 | $112.25 |
| 10 mg | $449 | $699 | $112.25 |
| 12.5 mg | $449 | $699 | $112.25 |
| 15 mg | $449 | $699 | $112.25 |
* The lower price for 7.5 mg and up applies on the first fill and on refills within 45 days of the previous delivery; otherwise the regular price applies.[7] Prices change: confirm before ordering. More on the cost page.
Related
- Pen vs vialAll four presentations side by side
- Compounded vs ZepboundHow approved vials differ from compounded ones
- Zepbound KwikPenFour fixed doses in one pen
- Dose scheduleWhich strength comes when
Frequently asked questions
How many units is a Zepbound vial?
A single-dose vial holds 0.5 mL, which is 50 units on a U-100 insulin syringe scale, whatever the strength. One dose from a multi-dose vial is 0.6 mL, or 60 units. The label itself measures in mL.
Can you get more than one dose out of a single-dose Zepbound vial?
No. The label says to inject the full contents and throw the vial away, even if medicine is left in it.[1]
How do you inject a Zepbound vial?
Draw the dose with a new 1 mL syringe to the 0.5 mL line (0.6 mL for a multi-dose vial), inject under the skin of the abdomen or thigh (or upper arm, by someone else), and hold the needle in for at least 5 seconds. Follow the Instructions for Use.[1]
What syringe do I use for a Zepbound vial?
The label says “a 1 mL syringe capable of measuring a 0.5 mL or 0.6 mL dose”, new for each injection. It is bought separately.[1]
How long can a Zepbound vial stay out of the fridge?
A single-dose vial can be kept at up to 30 °C (86 °F) for a total of 21 days. An unopened multi-dose vial can be kept at up to 30 °C for 30 days.[1]
Sources
- Zepbound (tirzepatide) injection: prescribing information, Medication Guide and Instructions for Use
- Drugs@FDA: NDA 217806 (Zepbound) approval history and supplement letters
- Lilly releases Zepbound single-dose vials, expanding supply and access
- Lilly launches additional Zepbound vial doses and offers new savings for self-pay patients
- Lilly to offer all approved doses of Zepbound single-dose vials through LillyDirect
- Zepbound supplement approval letter S-037 (multi-dose vial)
- Zepbound on LillyDirect: formats and self-pay prices