Published prices onlyEvery figure here is a price Eli Lilly itself published, with the date it was published or checked.[1][5] We do not list coupons, discount cards or places to buy, and we receive nothing from any seller. Prices change; confirm the current one with your pharmacy or insurer.
How much is Zepbound without insurance?
Without insurance, Zepbound costs $299 to $699 per 4 weekly doses at Lilly's self-pay prices, depending on the strength and on refill timing. A fill is four weekly doses: four single-dose vials or one KwikPen. The lower price for 7.5 mg and up applies on the first fill and on refills within 45 days of the previous delivery; otherwise the regular price applies.[1]
| Strength | Per fill (4 doses) | Per weekly dose | Per mg | Regular price | Per mg at regular |
|---|---|---|---|---|---|
| 2.5 mg | $299 | $74.75 | $29.90 | $299 | $29.90 |
| 5 mg | $399 | $99.75 | $19.95 | $399 | $19.95 |
| 7.5 mg | $449 | $112.25 | $14.97 | $499 | $16.63 |
| 10 mg | $449 | $112.25 | $11.23 | $699 | $17.48 |
| 12.5 mg | $449 | $112.25 | $8.98 | $699 | $13.98 |
| 15 mg | $449 | $112.25 | $7.48 | $699 | $11.65 |
Arithmetic: per weekly dose = fill price ÷ 4; per mg = fill price ÷ (strength × 4). At 15 mg, $449 buys 60 mg, which is $7.48 per mg, against $29.90 per mg at 2.5 mg.
Cost of the first 20 weeks on the label schedule
If each 4-week step of the label escalation is taken at the earliest point, and every refill is on time:
| Weeks | Dose | Fill price | Running total |
|---|---|---|---|
| 1–4 | 2.5 mg | $299 | $299 |
| 5–8 | 5 mg | $399 | $698 |
| 9–12 | 7.5 mg | $449 | $1,147 |
| 13–16 | 10 mg | $449 | $1,596 |
| 17–20 | 12.5 mg | $449 | $2,045 |
From then on, any strength from 7.5 to 15 mg is $449 per 4 weeks with on-time refills: $5,837 for 13 fills, which covers 52 weeks.
A year at one dose
A year at one dose takes 13 fills: $3,887 at 2.5 mg and $5,837 at 7.5–15 mg with on-time refills.
| Strength | On-time refill price | Regular price |
|---|---|---|
| 2.5 mg | $3,887 | $3,887 |
| 5 mg | $5,187 | $5,187 |
| 7.5 mg | $5,837 | $6,487 |
| 10 mg | $5,837 | $9,087 |
| 12.5 mg | $5,837 | $9,087 |
| 15 mg | $5,837 | $9,087 |
Zepbound price with insurance
With insurance, the price depends on the plan, so there is no single published figure. What Lilly does publish is the list price, which is the starting point for insurers, and the self-pay prices above, which apply without insurance.[1][5] Lilly's own pharmacy page lists the single-dose pen for insured patients and the single-dose vials as self-pay only.[1]
Does Medicare cover Zepbound?
Medicare Part D excludes drugs used for weight loss but covers Zepbound for sleep apnea, and the temporary Medicare GLP-1 Bridge (July 1, 2026 to December 31, 2027) covers the Zepbound KwikPen for weight loss at $50 a month for eligible enrollees; single-dose vials and pens are not included.[7][8] Eligibility, prior authorization and Medicaid are on Zepbound insurance coverage.
Is there a generic Zepbound?
No. Drugs@FDA lists only Eli Lilly's two tirzepatide applications, Zepbound and Mounjaro, and no generic tirzepatide.[9][10] Compounded tirzepatide is not a generic: it is not FDA-approved.[12] Exclusivity, patents and the generic applications already filed are on generic Zepbound.
Zepbound vs Mounjaro vs Wegovy prices
Each maker publishes a list price, and Lilly and Novo Nordisk also publish self-pay prices.[5][6][11]
| Medicine | List price | Maker self-pay price |
|---|---|---|
| Zepbound (tirzepatide) | $1,059.87 at 2023 launch | $299–$449 with on-time refills; up to $699 |
| Mounjaro (tirzepatide) | $1,112.16 per 28 days | — |
| Wegovy injection (semaglutide) | $1,349.02 per package | $349 (0.25–2.4 mg); $399 (7.2 mg) |
The Wegovy comparison continues on Zepbound vs Wegovy.
Zepbound list price
List prices run from $1,059.87 (Zepbound at its 2023 launch) to $1,112.16 (Mounjaro, per 28 days), far above the self-pay vial prices.[5][6]
- Zepbound: Lilly set “a list price of $1,059.87” at approval in November 2023.[5] We could not verify the current list price from a Lilly page.
- Mounjaro: “The current list price for a 28-day supply of Mounjaro is $1,112.16.”[6]
List price is what the manufacturer charges wholesalers before discounts and rebates. Most people pay something different.
How the self-pay vial price has changed
Self-pay vial prices have fallen since launch: 2.5 mg went from $399 in 2024 to $299 in 2026.[2][1]
| Date | 2.5 mg | 5 mg | 7.5 mg | 10 mg | 12.5 mg | 15 mg |
|---|---|---|---|---|---|---|
| Aug 27, 2024[2] | $399 | $549 | – | – | – | – |
| Feb 25, 2025[3] | $349 | $499 | $499* ($599) | $499* ($699) | – | – |
| Jun 16, 2025[4] | $349 | $499 | $499* ($599) | $499* ($699) | $499* ($849) | $499* ($1,049) |
| Nov 13, 2026[1] | $299 | $399 | $449* ($499) | $449* ($699) | $449* ($699) | $449* ($699) |
A dash means that strength was not yet sold as a vial. The 12.5 and 15 mg vials began shipping in August 2025.[4]
Related
- Pen vs vialWhich presentation costs what
- Zepbound vial guideStrengths and storage
- Zepbound vs MounjaroSame drug, different labels and prices
Frequently asked questions
How much does Zepbound cost without insurance?
On LillyDirect as of November 13, 2026: $299 for 2.5 mg and $399 for 5 mg per 4 doses; $449 for 7.5 to 15 mg with on-time refills, otherwise $499 (7.5 mg) or $699 (10 to 15 mg).[1]
Why is the price the same for 7.5 mg and 15 mg?
Lilly sets one on-time refill price for all strengths from 7.5 mg up.[1] Per milligram, that makes 15 mg the lowest-cost strength.
What is the list price of Zepbound?
How much does tirzepatide cost per mg?
At Lilly's self-pay prices, from $29.90 per mg at 2.5 mg down to $7.48 per mg at 15 mg with on-time refills.[1]
How much is Zepbound with Medicare?
Is there a generic Zepbound?
Is the KwikPen cheaper than vials?
No. On LillyDirect the KwikPen and four single-dose vials have the same self-pay price for each strength.[1]
Sources
- Zepbound on LillyDirect: formats and self-pay prices
- Lilly releases Zepbound single-dose vials, expanding supply and access
- Lilly launches additional Zepbound vial doses and offers new savings for self-pay patients
- Lilly to offer all approved doses of Zepbound single-dose vials through LillyDirect
- FDA approves Lilly's Zepbound (tirzepatide) for chronic weight management
- Mounjaro FAQ (list price)
- Medicare GLP-1 Bridge
- Medicare GLP-1 Bridge: information for providers
- Drugs@FDA: NDA 217806 (Zepbound) approval history and supplement letters
- Drugs@FDA: NDA 215866 (Mounjaro) approval history and supplement letters
- Wegovy cost, coverage and self-pay prices (NovoCare)
- FDA's concerns with unapproved GLP-1 drugs used for weight loss